Trey Luker-Stewart, like millions of other Americans, used GLP-1s for weight loss. In 2025, it was reported that around 12 to 14 percent of the American population were using GLP-1 drugs for weight loss purposes, and Trey was one of them. He used Ozempic to reach his goal weight and successfully lost 60 pounds. While he was pleased with his achievements, he began to notice unexpected side effects—especially when it came to alcohol. Once describing himself as “a super happy drunk,” he found that after starting GLP-1 medication, drinking made him feel far more emotional, anxious, and prone to overthinking.
Speaking about his experience, Trey explained that something which used to be fun now left him feeling upset and sensitive. Alongside the emotional changes, he also began experiencing much harsher hangovers. Previously, he could wake up early after a night of drinking and go about his day productively, but after starting the medication, even a couple of drinks would leave him feeling unwell until midday. The shift significantly changed his relationship with alcohol, making it less enjoyable overall.
Trey, a real estate agent and bar owner in Dallas, Texas, believes he’s not alone in this experience. He claims alcohol sales in the city have dropped noticeably and suggests that the growing use of GLP-1 drugs could be a contributing factor. Although he stopped taking the medication regularly after about six months, returning only to a monthly dose to maintain his weight loss, he noted that while his appetite came back, his previous tolerance and enjoyment of alcohol did not.
Studies have explored how GLP-1 drugs interact with alcohol, with some suggesting that people on these medications may not feel drunk as easily because the drugs slow the rate at which alcohol enters the bloodstream. This can reduce alcohol’s effects and potentially lead to lower consumption. However, experts also warn that combining GLP-1 medications with alcohol can lower blood sugar levels, irritate the stomach, and in some cases contribute to more serious issues such as liver strain or pancreatitis, meaning users should be cautious.